Immunitrack and the University of Copenhagen publish a joint paper on the performance of 15 HLA-epitope-binding prediction tools.
In this paper, we present 174 novel COVID-19 epitopes that can be used for COVID-19 vaccine development and immune monitoring of patients.
The current COVID-19 pandemic highlights the need for fast and efficacious vaccine development. Vaccine efficacy is highly dependent on the stimulation of a proper T cell response. Since the COVID-19 proteome is large, testing of overlapping epitopes by ELISpot or in vitro binding assays is an insurmountable task.
HLA-epitope-binding prediction tools are therefore an attractive approach to narrow down the number of candidate peptides to test. In this study we assessed the performance of 15 HLA-epitope-binding prediction tools across 11 MHC allotypes using a subset of 777 epitopes derived from SARS-CoV-2 and used actual epitope binding stability data as a benchmark.
The outcome was that these prediction tools vary greatly in performance across MHC allotypes. In addition, we present 174 novel epitopes that may contribute to the design of an efficacious vaccine against COVID-19.
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Stephan Thorgrimsen, CEO